Chemical Name: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
Biological ActivityNSC 95397 is a potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (Ki values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G2/M phase transition in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors.
Han et al.
Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation.
Melchheier et al.
Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors.
Lazo et al.
Citation for NSC 95397
The citations listed below are publications that use Tocris products. Selected citations for NSC 95397 include:
1 Citation: Showing 1 - 1
Cysteine 81 is critical for the interaction of S100A4 and myosin-IIA.
Authors: Dulyaninova Et al.
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