NSC 95397

Key Product Details

Product Description

NSC 95397 is a potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (K_i values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G₂/M phase transition in vitro.

Product Specifications for NSC 95397

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for NSC 95397

The following data is based on the product molecular weight 310.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	6.44 mL	32.22 mL	64.44 mL
2.5 mM	1.29 mL	6.44 mL	12.89 mL
5 mM	0.64 mL	3.22 mL	6.44 mL
25 mM	0.13 mL	0.64 mL	1.29 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Lazo Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Mol.Pharmacol. 2002 PMID: 11901209
• Melchheier Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation. Biochem.Biophys.Res.Commun. 2005 PMID: 15652497
• Han NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. J.Pharmacol.Exp.Ther. 2004 PMID: 14718602

Product Documents for NSC 95397