NSC 95397
Chemical Name: 2,3-bis[(2-Hydroxyethyl)thiol]-1,4-naphthoquinone
Purity: ≥97%
Biological Activity
NSC 95397 is a potent and selective irreversible inhibitor of Cdc25 dual specificity phosphatases (Ki values are 32, 96 and 40 nM for inhibition of Cdc25A, -B and -C respectively). Displays 125 - 180-fold selectivity over VH1-related dual-specificity phosphatase and protein tyrosine phosphatase 1b. Inhibits carcinoma cell growth and blocks G2/M phase transition in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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NAD(P)H:Quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors.
Han et al.
J.Pharmacol.Exp.Ther., 2004;309:64 -
Quinone-induced Cdc25A inhibition causes ERK-dependent connexin phosphorylation.
Melchheier et al.
Biochem.Biophys.Res.Commun., 2005;327:1016 -
Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors.
Lazo et al.
Mol.Pharmacol., 2002;61:720
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Citation for NSC 95397
The citations listed below are publications that use Tocris products. Selected citations for NSC 95397 include:
1 Citation: Showing 1 - 1
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Cysteine 81 is critical for the interaction of S100A4 and myosin-IIA.
Authors: Dulyaninova Et al.
Biochemistry 2011;50:7218
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