NVP BSK 805

Catalog # Availability Size / Price Qty
5818/50
5818/10

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NVP BSK 805 | CAS No. 2320258-95-3 | JAK Kinase Inhibitors
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Description: Potent JAK2 inhibitor; orally bioavailable

Chemical Name: 8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline trihydrochloride

Purity: ≥98%

Product Details
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Biological Activity

NVP BSK 805 is a potent JAK2 inhibitor (IC50 = 0.48 nM). Exhibits >20-fold selectivity for JAK2 over TYK2, JAK3 and JAK1 (IC50 values are 10.8, 18.7 and 31.6 nM, respectively). Inhibits proliferation and induces apoptosis of JAK2V617F-bearing acute myeloid leukemia cells in vitro and in vivo. Also inhibits erythropoietin-induced polycythemia. Orally bioavailable.

Technical Data

M.Wt:
599.94
Formula:
C27H28F2N6O.3HCl
Solubility:
Soluble to 50 mM in DMSO and to 100 mM in water
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2320258-95-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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