NVP CXCR2 20
Chemical Name: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile
Biological ActivityPotent and selective CXCR2 antagonist (IC50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists.
Porter et al.
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VersaClone cDNA Plasmids
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