NVP CXCR2 20

Catalog # Availability Size / Price Qty
5660/10
5660/50
Cat.No. 5660 - NVP CXCR2 20 | C15H11F2N3OS | CAS No. 1029521-30-9
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Description: Potent and selective CXCR2 antagonist

Chemical Name: 4-Cyclopropyl-2-[[(2,3-difluorophenyl)methyl]thio]-1,6-dihydro-6-oxo5-pyrimidinecarbonitrile

Purity: ≥98%

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Biological Activity

Potent and selective CXCR2 antagonist (IC50 = 40 nM). Exhibits selectivity for CXCR2 over a panel of 49 other GPCRs. Orally bioavailable.

Technical Data

M.Wt:
319.33
Formula:
C15H11F2N3OS
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1029521-30-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists.
    Porter et al.
    Bioorg.Med.Chem.Lett., 2014;24:3285

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