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NX 2127

Catalog #: 8951 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
8951/5

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NX 2127 | CAS No. 3024312-52-2 | Active Degraders
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Description: Potent BTK Degrader (PROTAC®)

Chemical Name: 3-[[4-[1-[[(3R)-1-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-3-pyrrolidinyl]methyl]-4-piperidinyl]phenyl]amino]-5-(1-piperidinyl)-2-pyrazinecarboxamide

Purity: ≥98%

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Biological Activity

NX 2127 is a potent BTK Degrader (PROTAC®) (DC50 = 4.5 nM and Dmax = 94%). It comprises a BTK binding moiety joined by a linker to a cereblon (CRBN) ligand. NX 2127 also degrades the transcription factors IKZF1 and IKZF3 (DC50 = 57 and 36 nM, respectively). In vivo, NX 2127 possesses potent target degradation activity across species and demonstrates efficacy in preclinical oncology models. NX 2127 is orally bioavailable.

Technical Data

M.Wt:
719.85
Formula:
C39H45N9O5
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
3024312-52-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Nurix Therapeutics

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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