O8 OGG1 Inhibitor
Chemical Name: 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide
Biological ActivityPotent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1).
Donley et al.
ACS Chem.Biol., 2015;10:2334
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