O8 OGG1 Inhibitor

Catalog # Availability Size / Price Qty
6236/5
6236/25
Cat.No. 6236 - O8 OGG1 Inhibitor | C9H6Cl2N2OS | CAS No. 350997-39-6
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Description: Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor

Chemical Name: 3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide

Purity: ≥98%

Product Details
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Biological Activity

Potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.

Technical Data

M.Wt:
261.13
Formula:
C9H6Cl2N2OS
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
350997-39-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Small molecule inhibitors of 8-oxoguanine DNA glycosylase-1 (OGG1).
    Donley et al.
    ACS Chem.Biol., 2015;10:2334

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