Chemical Name: Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
Biological ActivityOB-1 is a stomatin-like protein-3 (STOML3) oligomerization inhibitor. Reduces STOML3 cluster size in the plasma membrane. Decreases mechanically-induced Piezo1 but not ASIC3 current amplitudes in N2a cells and cultured mouse sensory neurons in vitro. Subcutaneous administration in mice reversibly silences touch receptor activity and inhibits paw withdrawal reflex in a mouse neuropathic pain model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.
Wetzel et al.
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