Invertebrate biogenic amine neurotransmitter, related to noradrenalin, that is an adrenoceptor agonist. Stimulates lipolysis in mammalian adipocytes via activation of β3
receptors. Has dual effect on glucose transport in adipocytes: inhibits transport via β3
receptor activation but stimulates transport when oxidized by MAO. Also activates human α2A
receptors, inhibiting subsequent cAMP production.
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Selective inhibition of adenylyl cyclase by octopamine via a human cloned α2A-adrenoceptor.
Airriess et al.
Octopamine in invertebrates.
Dual action of octopamine on glucose transport into adipocytes: inhibition via β3-adrenoceptor activation and stimulation via oxidation by amine oxidases.
Visentin et al.
Selective activation of β3-adrenoceptors by octopamine: comparative studies in mammalian fat cells.
Carpene et al.