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Octopamine hydrochloride

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Octopamine hydrochloride | CAS No. 770-05-8 | Trace Amine 1 (TA1) Receptor Agonists
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Description: Invertebrate biogenic amine: activates β3 adrenoceptors
Alternative Names: (±)-p-Octopamine, Epirenor, Norfen

Chemical Name: α-(Aminomethyl)-4-hydroxybenzenemethanol hydrochloride

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Invertebrate biogenic amine neurotransmitter, related to noradrenalin, that is an adrenoceptor agonist. Stimulates lipolysis in mammalian adipocytes via activation of β3 receptors. Has dual effect on glucose transport in adipocytes: inhibits transport via β3 receptor activation but stimulates transport when oxidized by MAO. Also activates human α2A receptors, inhibiting subsequent cAMP production.

Technical Data

M.Wt:
189.64
Formula:
C8H11NO2.HCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
770-05-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dual action of octopamine on glucose transport into adipocytes: inhibition via β3-adrenoceptor activation and stimulation via oxidation by amine oxidases.
    Visentin et al.
    J.Pharmacol.Exp.Ther., 2001;299:96
  2. Selective inhibition of adenylyl cyclase by octopamine via a human cloned α2A-adrenoceptor.
    Airriess et al.
    Br.J.Pharmacol., 1997;122:191
  3. Octopamine in invertebrates.
    Roeder
    Prog.Neurobiol., 1999;59:533
  4. Selective activation of β3-adrenoceptors by octopamine: comparative studies in mammalian fat cells.
    Carpene et al.
    Naunyn-Schmied.Arch.Pharmacol., 1999;359:310

Product Datasheets

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Citation for Octopamine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Octopamine hydrochloride include:

1 Citation: Showing 1 - 1

  1. Pericytes impair capillary blood flow and motor function after chronic spinal cord injury.
    Authors: Li Et al.
    Nat Med  2017;23:733

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VersaClone cDNA Plasmids

Human ADRB3 (NP_000016) VersaClone cDNA

RDC0261

Mouse beta-3 Adrenergic R/ADRB3 (NP_038490) VersaClone cDNA

RDC0665

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