OD 36 hydrochloride
Chemical Name: 6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride
Purity: ≥98%
Biological Activity
OD 36 hydrochloride is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
Tigno-Aranjuez et al.
J.Biol.Chem., 2014;289:29651 -
Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cells.
S?nchez-Duffhues et al.
JBMRPlus, 2019;3:e10230
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