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OD 36 hydrochloride

6598 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6598/10
Other Kinase Inhibitors Small Molecule
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Description: Potent RIPK2 inhibitor

Chemical Name: 6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hydrochloride

Purity: ≥98%

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Biological Activity

Potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.

Technical Data

M.Wt:
367.23
Formula:
C16H15ClN4O2.HCl
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1638644-62-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. In vivo inhibition of RIPK2 kinase alleviates inflammatory disease.
    Tigno-Aranjuez et al.
    J.Biol.Chem., 2014;289:29651

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