OD 36 hydrochloride

Key Product Details

Product Description

OD 36 hydrochloride is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC₅₀ = 5.3 nM). Displays similar % inhibition against ALK-2 and SIK2 at 100 nM. Downregulates expression of a panel of RIPK2-dependent genes. Inhibits recruitment of inflammatory cells in a mouse MDP-induced peritonitis model.

Product Specifications for OD 36 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OD 36 hydrochloride

The following data is based on the product molecular weight 367.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.72 mL	13.62 mL	27.23 mL
5 mM	0.54 mL	2.72 mL	5.45 mL
10 mM	0.27 mL	1.36 mL	2.72 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sánchez-Duffhues Development of macrocycle kinase inhibitors for ALK2 using Fibrodysplasia ossificans progressiva-derived endothelial cells. JBMRPlus 2019 PMID: 31768489
• Tigno-Aranjuez In vivo inhibition of RIPK2 kinase alleviates inflammatory disease. J.Biol.Chem. 2014 PMID: 25213858

Product Documents for OD 36 hydrochloride