Potent rat Nav
1.7, human Nav
1.4 and rat Nav
1.6 channel activator (EC50
values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav
1.3 and Nav
values >3 μ
M). Inhibits fast inactivation on all channels. Increases peak currents at all voltages and stimulates a persistent Na+
current at hNav
1.7 channel. Increases hyperpolarization at Nav
1.4 and Nav
1.6 channels. Induces spontaneous pain in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1.
Durek et al.
ACS Chem.Biol., 2013;8:1215
OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels.
Jalali et al.
FEBS Lett., 2005;579:4181
Potent modulation of the voltage-gated sodium channel Nav1.7 by OD1, a toxin from the scorpion Odonthobuthus doriae.
Maertens et al.