OF 1

Key Product Details

Product Description

OF 1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (K_d values are 100 and 500 nM respectively). Exhibits 39-fold selectivity for BRPF1B and BRPF2 over BRD4. Accelerates FRAP recovery at 5 μM in a BRPF2 FRAP assay. Inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the OF 1 probe summary on the SGC website.

Product Specifications for OF 1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OF 1

The following data is based on the product molecular weight 440.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.36 mL	56.78 mL	113.56 mL
1 mM	2.27 mL	11.36 mL	22.71 mL
2 mM	1.14 mL	5.68 mL	11.36 mL
10 mM	0.23 mL	1.14 mL	2.27 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Meier Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation. ACS Chem.Biol. 2017 PMID: 28849908

Product Documents for OF 1