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OF 1

Catalog #: 5289 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5289/10
5289/50
OF 1 | CAS No. 919973-83-4 | Bromodomain Inhibitors
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Description: Selective BRPF1B and BRPF2 inhibitor

Chemical Name: 4-Bromo-N-(2,3-dihydro-6-methoxy-1,3-dimethyl-2-oxo-1H-benzimidazol-5-yl)-2-methylbenzenesulfonamide

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

OF 1 is a selective BRPF1B and BRPF2 bromodomain inhibitor (Kd values are 100 and 500 nM respectively). Exhibits 39-fold selectivity for BRPF1B and BRPF2 over BRD4. Accelerates FRAP recovery at 5 μM in a BRPF2 FRAP assay. Inhibits RANKL-induced differentiation of primary murine bone marrow cells and human primary monocytes into osteoclasts.

Technical Data

M.Wt:
440.31
Formula:
C17H18BrN3O4S
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
919973-83-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the OF 1 probe summary on the SGC website.

Product Datasheets

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