Catalog Number: 2710
Chemical Name: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid
Biological Activity
Heparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).
Technical Data
  • M.Wt:
    495.3
  • Formula:
    C24H16BrFN2O4
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    853929-59-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Heparanase: a target for drug discovery in cancer and inflammation.
    McKenzie
    Br.J.Pharmacol., 2007;151:1
  2. Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor.
    Courtney et al.
    Bioorg.Med.Chem.Letts., 2005;15:2295

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