Chemical Name: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleacetic acid
Biological ActivityOGT 2115 is a heparanase inhibitor (IC50 = 0.4 μM) that displays no major inhibition of human cytochrome P450 isoenzymes (IC50 > 30 μM). Exhibits antiangiogenic properties in vitro (IC50 = 1 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Heparanase: a target for drug discovery in cancer and inflammation.
Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivates: novel classes of heparanase inhibitor.
Courtney et al.
Citations for OGT 2115
The citations listed below are publications that use Tocris products. Selected citations for OGT 2115 include:
4 Citations: Showing 1 - 4
Heparanase attenuates axon degeneration following sciatic nerve transection.
Sci Rep 2018;8(1):5219
Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1.
Authors: Agelidis Et al.
Cell Rep 2017;20:439
Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats.
Authors: Changyaleket Et al.
J Neuroinflammation 2017;14:137
Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components.
PLoS Pathogens 2017;13(11):e1006673
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