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Oligomycin A

Catalog #: 4110
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4110/5
Oligomycin A | CAS No. 579-13-5 | Other ATPase Inhibitors
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Description: Inhibitor of mitochondrial ATPase

Chemical Name: (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Oligomycin A is an inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.

Technical Data

M.Wt:
791.06
Formula:
C45H74O11
Solubility:
Soluble to 10 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
579-13-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase.
    Salomon et al.
    Chem.Biol., 2001;8:71

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Citations for Oligomycin A

The citations listed below are publications that use Tocris products. Selected citations for Oligomycin A include:

3 Citations: Showing 1 - 3

  1. Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells.
    Authors: Depaoli Et al.
    Cell Rep  2018;25:501
  2. Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.
    Authors: Shin Et al.
    Cell Metab  2017;26:764
  3. PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
    Authors: Banh Et al.
    Nat Cell Biol  2016;18:803

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