Chemical Name: (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Biological ActivityOligomycin A is an inhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase.
Salomon et al.
Citations for Oligomycin A
The citations listed below are publications that use Tocris products. Selected citations for Oligomycin A include:
3 Citations: Showing 1 - 3
Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells.
Authors: Depaoli Et al.
Cell Rep 2018;25:501
Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.
Authors: Shin Et al.
Cell Metab 2017;26:764
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Authors: Banh Et al.
Nat Cell Biol 2016;18:803
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Reviews for Oligomycin A
Average Rating: 4 (Based on 1 Review)
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Oligomycin A was used in oxidative phosphorylation studies. Its action on protein channel blocking was being studied. Performed well and gives repeatable results.