Chemical Name: (1R,4E,5'S,6S,6'S,7R,8S,10R,11R, 12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione
Biological ActivityInhibitor of mitochondrial ATP synthase and uncoupler of oxidative phosphorylation. Antibiotic; exhibits anti-tumor activity.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase.
Salomon et al.
Citations for Oligomycin A
The citations listed below are publications that use Tocris products. Selected citations for Oligomycin A include:
3 Citations: Showing 1 - 3
Real-Time Imaging of Mitochondrial ATP Dynamics Reveals the Metabolic Setting of Single Cells.
Authors: Depaoli Et al.
Cell Rep 2018;25:501
Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice.
Authors: Shin Et al.
Cell Metab 2017;26:764
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Authors: Banh Et al.
Nat Cell Biol 2016;18:803
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Reviews for Oligomycin A
Average Rating: 4 (Based on 1 Review)
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Oligomycin A was used in oxidative phosphorylation studies. Its action on protein channel blocking was being studied. Performed well and gives repeatable results.