Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Biological ActivityOlmesartan is a potent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure.
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In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies.
Ojima et al.
Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmes.
Mogi et al.
Effects of olmes. on arterial stiffness in rats with chronic renal failure.
Chuang et al.
Citation for Olmesartan
The citations listed below are publications that use Tocris products. Selected citations for Olmesartan include:
1 Citation: Showing 1 - 1
A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
J Biol. Chem. 2021;296:100503
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