Potent angiotensin II type I (AT1
) receptor antagonist (IC50
= 6.7 nM at hAT1
receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure. Metabolite of Olmesartan medoxomil
(Cat. No. 4620).
Soluble to 20 mM in DMSO
Store at +4°C
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All Tocris products are intended for laboratory research use only.
In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies.
Ojima et al.
Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan.
Mogi et al.
Effects of olmesartan on arterial stiffness in rats with chronic renal failure.
Chuang et al.