Olmesartan
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Purity: ≥99%
Biological Activity
Olmesartan is a potent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure.Technical Data
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies.
Ojima et al.
J.Pharmacol.Exp.Ther., 2011;336:801 -
Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmes.
Mogi et al.
Neuropharmacology, 2007;53:899 -
Effects of olmes. on arterial stiffness in rats with chronic renal failure.
Chuang et al.
Cardiovasc.Diabetol., 2012;11:66
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Citation for Olmesartan
The citations listed below are publications that use Tocris products. Selected citations for Olmesartan include:
1 Citation: Showing 1 - 1
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A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
Authors: Pedersen
J Biol. Chem. 2021;296:100503
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