Olmesartan

Key Product Details

Product Description

Olmesartan is a potent angiotensin II type I (AT₁) receptor antagonist (IC₅₀ = 6.7 nM at hAT₁ receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure.

Product Specifications for Olmesartan

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Olmesartan

The following data is based on the product molecular weight 446.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.20 mL	55.99 mL	111.98 mL
1 mM	2.24 mL	11.20 mL	22.40 mL
2 mM	1.12 mL	5.60 mL	11.20 mL
10 mM	0.22 mL	1.12 mL	2.24 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Chuang Effects of olmes. on arterial stiffness in rats with chronic renal failure. Cardiovasc.Diabetol. 2012 PMID: 22694778
• Ojima In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies. J.Pharmacol.Exp.Ther. 2011 PMID: 21123673
• Mogi Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmes. Neuropharmacology 2007 PMID: 18028965

Product Documents for Olmesartan