Olmesartan
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Description: Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620)
Chemical Name: 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
Purity: ≥99%
Biological Activity
Potent angiotensin II type I (AT1) receptor antagonist (IC50 = 6.7 nM at hAT1 receptors). Improves cognitive function in a mouse model of hypertension- and hyperlipidemia-associated cognitive decline; ameliorates arterial stiffness in a rat model of chronic renal failure. Metabolite of Olmesartan medoxomil (Cat. No. 4620).Technical Data
M.Wt:
446.5
Formula:
C24H26N6O3
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
144689-24-7
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
In vitro antagonistic properties of a new angiotensin type 1 receptor blocker, azilsartan, in receptor binding and function studies.
Ojima et al.
J.Pharmacol.Exp.Ther., 2011;336:801 -
Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan.
Mogi et al.
Neuropharmacology, 2007;53:899 -
Effects of olmesartan on arterial stiffness in rats with chronic renal failure.
Chuang et al.
Cardiovasc.Diabetol., 2012;11:66
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