4 results for "Angiotensin AT1 Receptor Antagonists" in Products
Angiotensin AT1 Receptor Antagonists
The angiotensin1 receptor (AT1) is a member of the angiotensin group of G-protein-coupled receptors that also includes AT2 and AT4. They are located primarily in the liver, kidney, adrenal gland and lung where they play a role in vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration and sympathetic stimulation. AT1 receptors preferentially bind angiotensin II.
Most species express a single AT1 gene, but two related genes AT1A and AT1B are found in rodents. The human AT1 receptor gene has been localized to chromosome 3 (3q21-q25).
Selective, non-peptide AT1 antagonist
| Alternate Names: | DuP-753 |
| Chemical Name: | 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol potassium salt |
| Purity: | ≥98% |
High affinity, selective AT1 antagonist
| Alternate Names: | CGP 48933 |
| Chemical Name: | (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)pentanamido]butanoic acid |
| Purity: | ≥98% |
Potent and selective AT1 antagonist
| Chemical Name: | 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid |
| Purity: | ≥98% |
Potent AT1 antagonist
| Chemical Name: | 2-Butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one |
| Purity: | ≥98% |
