ω-Conotoxin GVIA

Tocris Bioscience | Catalog # 1085

CaV2.2 blocker
Tocris Bioscience

Key Product Details

Description

CaV2.2 blocker
View all Cav2.x Channel Blockers »

Product Description

ω-Conotoxin GVIA is a peptide neurotoxin; selectively and reversibly blocks N-type calcium channels (IC50 = 0.15 nM). Reduces (RS)-3,5-DHPG (Cat. No. 0342)-induced long term depression in vivo.

Product Specifications for ω-Conotoxin GVIA

Molecular Weight

3037.00

Formula

C120H182N38O43S6

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

106375-28-4

PubChem ID

90479753

InChI Key

DRVGOMCWRXUORL-QPEMYEDGSA-N

SMILES

[H]N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)C4C(O)CCN4C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)CNC(=O)C4C(O)CCN4C(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](CO)C(=O)N1CCC(O)C1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N3)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 25 publications citing the usage of this product.

Product Documents for ω-Conotoxin GVIA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ω-Conotoxin GVIA

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for ω-Conotoxin GVIA

Customer Reviews for ω-Conotoxin GVIA (3)

4.7 out of 5
3 Customer Ratings
5 Stars
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4 Stars
33%
3 Stars
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1 Stars
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  • The pharmacological inhibitors for electrophysiology assay
    Name: Anonymous
    Species: skate
    Assay Type: In Vitro
    Verified Customer | Posted 02/28/2020
    The following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
    ω-Conotoxin GVIA 1085
  • The 5,760 bioactive compound library is a collated compound set of approved drugs and biologically active compound
    Name: Anonymous
    Species: C. albicans
    Assay Type: In Vitro
    Verified Customer | Posted 02/01/2020
    Biologically active compounds that have been documented to interact with a wide range of targets including SB-224289 (Cat. # 1221), MG-624 (Cat. # 1356), GVIA (Cat. No. 1085), DPAT hydrobromide (Cat. No. 1080) and valinomycin (VA; Cat. # 3373) were ordered from Tocris Bioscience
    ω-Conotoxin GVIA 1085
  • omega -Conotoxin suppresses field EPSP amplitude
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Cell Line/Tissue: Anterior cingulate cortex
    Verified Customer | Posted 06/12/2019
    Experiment to test dependence of field EPSPs in neural tissue from N-type Ca2+ channels. 10 min incubation with 25 microM omega -Conotoxin GVIA decreased significantly fEPSP amplitude. Blue: control. Red: after incubation with omega -Conotoxin GVIA.
    ω-Conotoxin GVIA 1085

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