Chemical Name: 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
Biological ActivityProapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
Guo et al.
Mol.Cancer Ther., 2009;8:441
Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota.
Guo et al.
Cancer Res., 2007;68:7403
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