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Oncrasin 1

3427 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3427/10
3427/50
Oncrasin 1 | CAS No. 75629-57-1 | Additional Protein Kinase C Compounds
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Description: Induces abnormal nuclear aggregation of PKCι; proapoptotic

Chemical Name: 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde

Purity: ≥98%

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Biological Activity

Proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.

Technical Data

M.Wt:
269.73
Formula:
C16H12ClNO
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
75629-57-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
    Guo et al.
    Mol.Cancer Ther., 2009;8:441
  2. Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota.
    Guo et al.
    Cancer Res., 2007;68:7403

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