Catalog Number: 3427
Chemical Name: 1-[(4-Chlorophenyl)methyl]-1H-indole-3-carboxaldehyde
Biological Activity
Proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
    Guo et al.
    Mol.Cancer Ther., 2009;8:441
  2. Identification of a small molecule with synthetic lethality for k-Ras and protein kinase C iota.
    Guo et al.
    Cancer Res., 2007;68:7403
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