Catalog Number: 4530
Alternate Names: Arundic acid
Chemical Name: (2R)-2-Propyloctanoic acid
Biological Activity
Inhibits S-100β synthesis in activated cultured astrocytes. Prevents delayed infarct expansion 24 hours after permanent middle cerebral artery occlusion (pMCAO) in rats; also exhibits neuroprotective effects in mouse models of Parkinson's disease and Alzheimer's disease.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Arundic acid, an astrocyte-modulating agent, protects dopaminergic neurons against MPTP neurotoxicity in mice.
    Kato et al.
    Brain Res., 2004;1030:66
  2. Astrocytic activation and delayed infarct expansion after permanent focal ischemia in rats. Part II: suppression of astrocytic activation by a novel agent (R)-(-)-2-propyloctanoic acid (ONO-2506) leads to mitigation of delayed infarct expansion and early
    Tateishi et al.
    J.Cereb.Blood Flow Metab., 2002;22:723
  3. Arundic acid ameliorates cerebral amyloidosis and gliosis in Alzheimer transgenic mice.
    Mori et al.
    J.Pharmacol.Exp.Ther., 2006;318:571
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