ONO 6818

Catalog # Availability Size / Price Qty

SAVE +FREE SHIPPING with ACADEMIA23 (See Promo Details)

ONO 6818 | CAS No. 208848-19-5 | Synthetic Elastase Inhibitors
1 Image
Description: High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor; orally active

Chemical Name: 5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide

Purity: ≥98%

Product Details

Biological Activity

ONO 6818 is a high affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM). Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits HNE-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active.

Technical Data

Soluble to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters.
    Hirota et al.
    J.Vet.Med.Sci., 2004;66:1223
  2. Serine proteases increase oxidative stress in lung cells.
    Aoshiba et al.
    Am.J.Physiol.Lung Cell Mol.Physiol., 2001;281:556
  3. AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase.
    Stevens et al.
    J.Pharmacol.Exp.Ther., 2011;339:313

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for ONO 6818

There are currently no reviews for this product. Be the first to review ONO 6818 and earn rewards!

Have you used ONO 6818?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.