Orai1 is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. Orai1 is a pore subunit of Ca(2+) release-activated Ca(2+) CRAC channels, and STIM1 acts as an endoplasmic reticulum (ER) Ca(2+) sensor that detects store depletion. This type of channel is the primary way for calcium influx into T-cells. Defects in Orai1 are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1.
Orai1 Antibody Blocking Peptide
Novus Biologicals | Catalog # NBP1-76762PEP
![Western Blot: Orai1 Antibody Blocking Peptide [NBP1-76762PEP]](https://resources.rndsystems.com/images/products/Orai1-Peptide-Western-Blot-NBP1-76762PEP-img0001.jpg "Western Blot: Orai1 Antibody Blocking Peptide [NBP1-76762PEP]")
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Key Product Details
Source
Synthetic
Applications
Antibody Competition
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Product Specifications
Description
A blocking peptide containing 18 amino acids near the amino terminus of human ORAI1.
Source: Synthetic
(Accession #: Q96D31)
Application Notes
This peptide is useful as a blocking peptide for NBP1-76762.
For further blocking peptide related protocol, click here.
For further blocking peptide related protocol, click here.
Protein / Peptide Type
Antibody Blocking Peptide
Scientific Data Images for Orai1 Antibody Blocking Peptide
Western Blot: Orai1 Antibody Blocking Peptide [NBP1-76762PEP]
Western Blot: Orai1 Peptide [NBP1-76762PEP] - blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37C.Formulation, Preparation, and Storage
NBP1-76762PEP
| Formulation | PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin. |
| Preservative | 0.02% Sodium Azide |
| Concentration | 0.2 mg/ml |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store at -20C. Avoid freeze-thaw cycles. |
Background: Orai1
Long Name
ORAI Calcium Release-activated Calcium Modulator 1
Alternate Names
CRACM1, ORAT1, TMEM142A
Gene Symbol
ORAI1
Additional Orai1 Products
Product Documents for Orai1 Antibody Blocking Peptide
Certificate of Analysis
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Product Specific Notices for Orai1 Antibody Blocking Peptide
This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.
Related Research Areas
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