Org 12962 hydrochloride
Chemical Name: 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine hydrochloride
Biological ActivitySelective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.
Porter et al.
Antiaversive effects of 5-HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.
Jenck et al.
Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity.
Halford et al.
Curr.Drug Targets, 2005;6:201
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