Catalog Number: 3585
Chemical Name: 1-[6-Chloro-5-trifluoromethyl)-2-pyridinyl]-piperazine hydrochloride
Biological Activity
Selective 5-HT2C receptor agonist (pEC50 values are 7.01, 6.38 and 6.28 for 5-HT2C, 5-HT2A and 5-HT2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.
Technical Data
  • M.Wt:
    302.12
  • Formula:
    C10H11ClF3N3.HCl
  • Solubility:
    Soluble to 50 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    210821-63-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Antiaversive effects of 5-HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats.
    Jenck et al.
    Eur.Neuropsychopharmacol., 1998;8:161
  2. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells.
    Porter et al.
    Br.J.Pharmacol., 1999;128:13
  3. Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity.
    Halford et al.
    Curr.Drug Targets, 2005;6:201

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