Org 12962 hydrochloride

Key Product Details

Product Description

Selective 5-HT_2C receptor agonist (pEC₅₀ values are 7.01, 6.38 and 6.28 for 5-HT_2C, 5-HT_2A and 5-HT_2B respectively). Displays antiaversive effects in a rat model of panic-like anxiety.

Product Specifications for Org 12962 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Org 12962 hydrochloride

The following data is based on the product molecular weight 302.12.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.31 mL	16.55 mL	33.10 mL
5 mM	0.66 mL	3.31 mL	6.62 mL
10 mM	0.33 mL	1.65 mL	3.31 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Porter Functional characterization of agonists at recombinant human 5-HT_2A, 5-HT_2B and 5-HT_2C receptors in CHO-K1 cells. Br.J.Pharmacol. 1999 PMID: 10498829
• Halford Serotonin (5-HT) drugs: effects on appetite expression and use for the treatment of obesity. Curr.Drug Targets 2005 PMID: 15777190
• Jenck Antiaversive effects of 5-HT_2C receptor agonists and fluox. in a model of panic-like anxiety in rats. Eur.Neuropsychopharmacol. 1998 PMID: 9716307

Product Documents for Org 12962 hydrochloride