Chemical Name: N-Methyl-N-[(3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propyl]-glycine
Biological ActivityOrg 24598 is a potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 < 4). Active in vivo.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity.
Williams et al.
Anal. Biochem., 2003;321:31
Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1).
Chue et al.
Discovery and SAR of org 24598-a selective glycine uptake inhibitor.
Brown et al.
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