Org 25543 hydrochloride

Catalog # Availability Size / Price Qty
4782/10
4782/50
Glycine Transporter Inhibitors Small Molecule
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Description: Potent and selective GlyT2 inhibitor

Chemical Name: N-[[1-(Dimethylamino)cyclopentyl]methyl]-3,5-dimethoxy-4-(phenylmethoxy)benzamide hydrochloride

Purity: ≥99%

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Biological Activity

Potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.

Technical Data

M.Wt:
448.98
Formula:
C24H32lN2O4.HCl
Solubility:
Soluble to 20 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
495076-64-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice.
    Morita K, Motoyama N, Kitayama T et al.
    J Pharmacol Exp Ther.
  2. The first potent and selective inhibitors of the glycine transporter type 2.
    Caulfield et al.
    J.Med.Chem., 2001;44:2679

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