Org 25543 hydrochloride

Key Product Details

Product Description

Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC₅₀ = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Ameliorates mechanical allodynia after partial sciatic nerve ligation injury in mice.

Product Specifications for Org 25543 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Org 25543 hydrochloride

The following data is based on the product molecular weight 448.98.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.14 mL	22.27 mL
5 mM	0.45 mL	2.23 mL	4.45 mL
10 mM	0.22 mL	1.11 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

• Morita Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice. J.Pharmacol.Exp.Ther. 2008 PMID: 18448867
• Caulfield The first potent and selective inhibitors of the glycine transporter type 2. J.Med.Chem. 2001 PMID: 11495577

Product Documents for Org 25543 hydrochloride