kinase inhibitor (EC50
= 0.1 μ
M for p38α
). Selective for p38α
over a panel of 48 other human kinases. Inhibits LPS-induced TNFα
release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha.
Mihara et al.