Org 48762-0

Catalog # Availability Size / Price Qty
6014/10
6014/50
Org 48762-0 | CAS No. 755753-89-0 | p38 Inhibitors
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Description: Selective p38α/β inhibitor; orally bioavailable

Chemical Name: 4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-2H-pyrazolo[3,4-b]pyridine

Purity: ≥98%

Product Details
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Biological Activity

Selective p38α and β kinase inhibitor (EC50 = 0.1 μM for p38α). Selective for p38α/β over a panel of 48 other human kinases. Inhibits LPS-induced TNFα release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.

Technical Data

M.Wt:
398.41
Formula:
C24H16F2N4
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
755753-89-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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