Catalog Number: 6014
Chemical Name: 4,6-Bis(4-fluorophenyl)-2-methyl-5-(4-pyridinyl)-2H-pyrazolo[3,4-b]pyridine
Biological Activity
Selective p38α and β kinase inhibitor (EC50 = 0.1 μM for p38α). Selective for p38α/β over a panel of 48 other human kinases. Inhibits LPS-induced TNFα release from PBMCs. Also inhibits cytokine release in an LPS-induced endotoxemia model in mice. Orally bioavailable.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNFalpha.
    Mihara et al.
    Br.J.Pharmacol., 2008;154:153
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