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Orphanin FQ (1-11)

3932 Datasheet / COA / SDS

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3932 has been discontinued.
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Orphanin FQ (1-11)
1 Image
Description: Potent NOP agonist; displays analgesic properties
Alternative Names: Nociceptin (1-11)
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Biological Activity

Orphanin FQ (1-11) is a peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.

Technical Data

M.Wt:
1098.2
Formula:
C49H75N15O14
Sequence:
FGGFTGARKSA
Solubility:
Soluble to 2 mg/ml in 20% acetonitrile / water
Storage:
Store at -20°C
CAS No:
178249-41-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pharmacological characterization of orphanin FQ/nociceptin and its fragments.
    Rossi et al.
    J.Pharmacol.Exp.Ther., 1997;282:858
  2. Orphanin FQ/nociceptin analgesia in the rat.
    Rossi et al.
    Brain Res., 1998;792:327
  3. Structure-activity relationship studies on the novel neuropeptide orphanin FQ.
    Reinscheid et al.
    J.Biol.Chem., 1996;271:14163

Product Datasheets

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