Orphanin FQ (1-11)
Biological ActivityOrphanin FQ (1-11) is a peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological characterization of orphanin FQ/nociceptin and its fragments.
Rossi et al.
Orphanin FQ/nociceptin analgesia in the rat.
Rossi et al.
Brain Res., 1998;792:327
Structure-activity relationship studies on the novel neuropeptide orphanin FQ.
Reinscheid et al.
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