Catalog Number: 3932
Alternate Names: Nociceptin (1-11)
Biological Activity
Peptide fragment containing amino acids 1-11 of Nociceptin (Cat. No. 0910). Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
Technical Data
  • M.Wt:
    1098.2
  • Formula:
    C49H75N15O14
  • Sequence:
    FGGFTGARKSA
  • Solubility:
    Soluble to 2 mg/ml in 20% acetonitrile / water
  • Storage:
    Store at -20°C
  • CAS No:
    178249-41-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological characterization of orphanin FQ/nociceptin and its fragments.
    Rossi et al.
    J.Pharmacol.Exp.Ther., 1997;282:858
  2. Orphanin FQ/nociceptin analgesia in the rat.
    Rossi et al.
    Brain Res., 1998;792:327
  3. Structure-activity relationship studies on the novel neuropeptide orphanin FQ.
    Reinscheid et al.
    J.Biol.Chem., 1996;271:14163

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