Nociceptin

  ( 13 citations )    
Product Datasheet
Catalog Number:0910
Alternate Names:Orphanin FQ
Chemical Name:
Product Details
Citations (13)
Supplemental Products
Reviews
Biological Activity
Endogenous ligand for the NOP opioid receptor (pKi = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pKi < 6).
Technical Data
  • M.Wt:
    1809
  • Formula:
    C79H129N27O22
  • Sequence:
    FGGFTGARKSARKLANQ
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    170713-75-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Nociceptin include:

13 Citations: Showing 1 - 10
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  1. The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours.
    Authors: Kelly Et al.
    Neurochem Res  2015;232:305
  2. Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.
    Authors: McIlwrath and Westlund
    J Cell Mol Med  2015;21:836
  3. Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
    Authors: Wang Et al.
    Psychopharmacology (Berl)  2015;19:2587
  4. Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats.
    Authors: Farrag Et al.
    BMC Complement Altern Med  2015;10:e0125566
  5. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats.
    Authors: Kallupi Et al.
    Neuropsychopharmacology  2014;39:1081
  6. Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain.
    Authors: Popiolek-Barczyk Et al.
    Biomed Res Int  2014;2014:762930
  7. Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats.
    Authors: Miranda-Morales Et al.
    Behav Brain Res  2013;245:137
  8. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
    Authors: Lee Et al.
    PLoS One  2011;36:2008
  9. S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.
    Authors: Kokkola Et al.
    BMC Cell Biol  2005;6:21
  10. Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
    Authors: Kuzmin Et al.
    Br J Pharmacol  2004;141:132
  11. Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors.
    Authors: McLeod Et al.
    World J Gastroenterol  2001;132:1175
  12. Further characterization of the ORL1 receptor-mediated inhibition of noradrenaline release in the mouse brain in vitro.
    Authors: Werthwein Et al.
    Br J Pharmacol  1999;127:300
  13. Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide.
    Authors: Giuliani and Maggi
    Br J Pharmacol  1996;118:1567
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VersaClone cDNA Plasmids
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Human ORL1/OPRL1 (NP_000904) VersaClone cDNA

RDC0163
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