Catalog Number: 0910
Alternate Names: Orphanin FQ
Biological Activity
Endogenous ligand for the NOP opioid receptor (pKi = 8.6). Has no significant activity at μ, δ or κ opioid receptors (pKi < 6).
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The orphan opioid receptor and its endogenous ligand-nociceptin/orphanin FQ.
    Henderson and McKnight
    TiPS, 1997;18:293
  2. Structure-activity relationships of nociceptin and related peptides: comparison with dynorphin A.
    Guerrini et al.
    Peptides, 2000;21:923
  3. Orphanin FQ: a neuropeptide that activates an opioid like G protein coupled receptor.
    Reinscheid et al.
    Science, 1995;270:792
  4. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
    Meunier et al.
    Nature, 1995;377:532

The citations listed below are publications that use Tocris products. Selected citations for Nociceptin include:

Showing Results 1 - 10 of 11

  1. The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours.
    Authors: Kelly Et al.
    Neurochem Res
  2. Pharmacological attenuation of chronic alcoholic pancreatitis induced hypersensitivity in rats.
    Authors: McIlwrath and Westlund
    J Cell Mol Med
  3. Buprenorphine-elicited alteration of adenylate cyclase activity in human embryonic kidney 293 cells coexpressing κ-, μ-opioid and nociceptin receptors.
    Authors: Wang Et al.
    Psychopharmacology (Berl)
  4. Modulation of voltage-gated Ca2+ channels by G protein-coupled receptors in celiac-mesenteric ganglion neurons of septic rats.
    Authors: Farrag Et al.
    BMC Complement Altern Med
  5. Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain.
    Authors: Popiolek-Barczyk Et al.
    Biomed Res Int
  6. Participation of the nociceptin/orphanin FQ receptor in ethanol-mediated locomotor activation and ethanol intake in preweanling rats.
    Authors: Miranda-Morales Et al.
    Behav Brain Res
  7. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
    Authors: Lee Et al.
    PLoS One
  8. S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.
    Authors: Kokkola Et al.
    BMC Cell Biol
  9. Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.
    Authors: Kuzmin Et al.
    Br J Pharmacol
  10. Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors.
    Authors: McLeod Et al.
    World J Gastroenterol
  11. Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide.
    Authors: Giuliani and Maggi
    Br J Pharmacol
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