Catalog # Availability Size / Price Qty
Ouabain | CAS No. 630-60-4 | Na+/K+ ATPase Inhibitors
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Description: Na+/K+ ATPase inhibitor

Chemical Name: 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide

Purity: ≥95%

Product Details
Citations (9)

Biological Activity

Ouabain is a selective Na+, K+-ATPase inhibitor. Cardiotonic agent. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.08 μM).

Technical Data

Soluble to 10 mM in water and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding.
    Croyle et al.
    Eur.J.Biochem., 1997;248:488
  2. Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes.
    Hosoi et al.
    J.Neurochem., 1997;69:2189
  3. Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment.
    Marjorie et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:203
  4. Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19.
    Ko et al.
    BioRxiv - Paper not yet peer reviewed, 2020;

Product Datasheets

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Citations for Ouabain

The citations listed below are publications that use Tocris products. Selected citations for Ouabain include:

9 Citations: Showing 1 - 9


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