Catalog Number: 1076
Chemical Name: 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
Biological Activity
Selective Na+, K+-ATPase inhibitor.
Technical Data
  • M.Wt:
    584.66
  • Formula:
    C29H44O12
  • Solubility:
    Soluble to 10 mM in water and to 100 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    630-60-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes.
    Hosoi et al.
    J.Neurochem., 1997;69:2189
  3. Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment.
    Marjorie et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:203
  4. Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding.
    Croyle et al.
    Eur.J.Biochem., 1997;248:488
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ouabain include:

4 Citations: Showing 1 - 4
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  1. Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
    Authors: Pál Et al.
    Nat Neurosci 2015;8:35
  2. The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport.
    Authors: Ismael-Badarneh Et al.
    PLoS One 2015;10:e0134175
  3. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res 2013;14:134
  4. Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria.
    Authors: Genda Et al.
    J Neurosci 2011;31:18275

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