Chemical Name: 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11α,14,19-pentahydoxycard-20(22)-enolide
Biological ActivityOuabain is a selective Na+, K+-ATPase inhibitor. Cardiotonic agent. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.08 μM).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Extensive random mutagenesis analysis of the Na/K+ ATPase alpha subunit identifies known and previously unidentified amino acid residues that alter ouabain sensitivity-implications for ouabain binding.
Croyle et al.
Isoform-specific up-regulation by ouabain of Na+, K+-ATPase in cultured rat astrocytes.
Hosoi et al.
Ouabain improves cardiac function in vivo in rats with heart failure after chronic but not acute treatment.
Marjorie et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1997;356:203
Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19.
Ko et al.
BioRxiv - Paper not yet peer reviewed, 2020;
Citations for Ouabain
The citations listed below are publications that use Tocris products. Selected citations for Ouabain include:
9 Citations: Showing 1 - 9
Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space.
Authors: Babola Et al.
Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activation.
Authors: Romanos Et al.
Commun Biol 2019;2:127
Pharmacological Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between Synaptic Activity and Astrocytic Volume Transient.
Authors: Woo Et al.
Exp Neurobiol 2019;28:30
A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells.
Authors: Zhang Et al.
J Biol Chem 2019;
The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis.
Authors: Yin Et al.
Nat Commun 2018;9:2815
Appearance of fast astrocytic component in voltage-sensitive dye imaging of neural activity.
Authors: Pál Et al.
Nat Neurosci 2015;8:35
The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport.
Authors: Ismael-Badarneh Et al.
PLoS One 2015;10:e0134175
The expression and relaxant effect of bitter taste receptors in human bronchi.
Authors: Grassin-Delyle Et al.
Respir Res 2013;14:134
Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria.
Authors: Genda Et al.
J Neurosci 2011;31:18275
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