hh OXA 06 dihydrochloride: R&D Systems
Catalog Number: 5182
Chemical Name: 2-Fluoro-N-[[4-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]methyl]benzenemethanamine dihydrochloride
Biological Activity
Potent ROCK inhibitor (IC50 = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro.
Technical Data
  • M.Wt:
    404.31
  • Formula:
    C21H18FN3.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion.
    Vigil et al.
    Cancer Res., 2012;72:5338

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