OXA 06 dihydrochloride

Key Product Details

Product Description

OXA 06 dihydrochloride is a potent ROCK inhibitor (IC₅₀ = 10 nM). Suppresses pMYPT1 and pCofilin levels in non-small cell lung carcinoma (NSCLC) cell lines. Also inhibits anchorage-independent growth of NSCLC cell lines in vitro.

Product Specifications for OXA 06 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for OXA 06 dihydrochloride

The following data is based on the product molecular weight 404.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.37 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Vigil ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion. Cancer Res. 2012 PMID: 22942252

Product Documents for OXA 06 dihydrochloride