Oxotremorine M

  ( 11 citations )    
Product Datasheet
Catalog Number:1067
Chemical Name:N,N,N-Trimethyl-4-(2-oxo-1-pyrolidinyl)-2-butyn-1-ammonium iodide
Product Details
Citations (11)
Biological Activity
Muscarinic receptor agonist. Also directly potentiates NMDA-mediated ion currents.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for Oxotremorine M include:

11 Citations: Showing 1 - 10
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  1. HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience.
    Authors: Ahsan Raza
    Nat Commun  2017;8(1):189
  2. Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability.
    Authors: Parent Et al.
    Proc Natl Acad Sci U S A  2015;9:284
  3. Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair.
    Authors: Abiraman Et al.
    PLoS One  2015;35:3676
  4. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Neurosci  2015;112:8124
  5. Characterization of ST14A Cells for Studying Modulation of Voltage-Gated Calcium Channels.
    Authors: Roberts-Crowley and Rittenhouse
    Front Behav Neurosci  2015;10:e0132469
  6. Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors.
    Authors: Wilke Et al.
    Nat Commun  2014;5:5540
  7. Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons.
    Authors: Won Et al.
    PLoS One  2012;7:e42602
  8. Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation.
    Authors: Daigle and Caron
    J Neurosci  2012;32:11461
  9. Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels.
    Authors: Buchanan Et al.
    Neuron  2010;68:948
  10. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons.
    Authors: Filippov Et al.
    PLoS One  2010;30:11068
  11. Tonic enhancement of endocannabinoid-mediated retrograde suppression of inhibition by cholinergic interneuron activity in the striatum.
    Authors: Narushima Et al.
    J Neurosci  2007;27:496
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