Biological ActivityOxytocin is a neurohypophyseal peptide. Stimulates uterine contraction and lactation.
(Modifications: Gly-9 = C-terminal amide, Disulfide bridge between 1 - 6)
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Vasopressin and oxyt. receptors in the central nervous system.
Barberis and Tribolle
Signal transduction pathways of the human V1-vascular V2-renal, V3-pituitary vasopressin and oxyt. receptors.
Thibonnier et al.
Prog.Brain Res., 1998;119:147
Citations for Oxytocin
The citations listed below are publications that use Tocris products. Selected citations for Oxytocin include:
6 Citations: Showing 1 - 6
Central and peripheral GLP-1 systems independently and additively suppress eating.
Authors: Brierley Et al.
BioRXiv - not yet peer reviewed 2020;
OXT can regulate myometrial smooth muscle excitability by inhibiting the Na+ -activated K+ channel, Slo2.1.
Authors: Ferreira Et al.
J Physiol 2019;597:137
OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons.
Authors: Xiao Et al.
Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice.
Authors: Rapanelli Et al.
Biol Psychiatry 2017;82:194
The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Authors: Nøhr Et al.
Neurochem Int 2017;102:105
Serotonergic neuron regulation informed by in vivo single-cell transcriptomics.
Authors: Spaethling Et al.
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VersaClone cDNA Plasmids
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Preincubation of slices in oxytocin (200 nM) resulted in an increase in holding current when compared to slices incubated in normal ACSF.
Applied to rat uterus and human smooth muscle