Chemical Name: 5-(acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate
Biological ActivityP-3FAX-Neu5Ac is a cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread.
Büll et al.
ACS Nano., 2015;9:733
Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome.
Rillahan et al.
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