P-3FAX-Neu5Ac

Tocris Bioscience | Catalog # 5760

Sialic acid analog; sialyltransferase inhibitor
Tocris Bioscience

Key Product Details

Description

Sialic acid analog; sialyltransferase inhibitor
View all Other Transferase Inhibitors »

Product Description

P-3FAX-Neu5Ac is a cell-permeable sialic acid analog. Deacetylation occurs intracellularly giving rise to a sialyltransferase inhibitor. Abolishes expression of SLex expression on HL-60 cells and reduces E-selectin and P-selectin binding. Prevents metastasis formation in a mouse lung metastasis model.

Product Specifications for P-3FAX-Neu5Ac

Molecular Weight

551.47

Formula

C22H30FNO14

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

5-(Acetylamino)-3,5-dideoxy-3-fluoro-D-erythro-α-L-manno-2-nonulopyranosonic acid methyl ester 2,4,7,8,9-pentaacetate

CAS Number

117405-58-0

PubChem ID

72698605

InChI Key

COXHVKPJIOSDPS-RTEYEINBSA-N

SMILES

FC1C(OC(C)=O)C(NC(C)=O)C([C@H](OC(C)=O)[C@H](OC(C)=O)COC(C)=O)OC(C(OC)=O)1OC(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.15 100
Ethanol 27.57 50

Preparing Stock Solutions for P-3FAX-Neu5Ac

The following data is based on the product molecular weight 551.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.81 mL 9.07 mL 18.13 mL
5 mM 0.36 mL 1.81 mL 3.63 mL
10 mM 0.18 mL 0.91 mL 1.81 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for P-3FAX-Neu5Ac

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for P-3FAX-Neu5Ac

For research use only

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