Catalog Number: 0938
Biological Activity
Binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain.
Technical Data
  • M.Wt:
    199.64
  • Formula:
    C9H10ClNO2
  • Solubility:
    Soluble to 10 mM in 1eq. NaOH and to 5 mM in water with gentle warming
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    7424-00-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effect of p-chlorophenylalanine at moderate dosage on 5-HT and 5-HIAA concentrations in brain regions of control and p-chloroamphetamine treated rats.
    Datla and Curzon
    Neuropharmacology, 1996;35:315
  2. The effects of DL-p-chlorophenylalanine and DL-α-methyl-p-tyrosine on the brain catecholamine, serotonin and free amino acid contents in rat.
    Koyuncuoglu et al.
    Psychopharmacologia, 1975;45:163
Citations:

The citations listed below are publications that use Tocris products. Selected citations for p-Chlorophenylalanine include:

2 Citations: Showing 1 - 2
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  1. NAD+ protects against EAE by regulating CD4+ T-cell differentiation.
    Authors: Tullius Et al.
    Nat Commun 2014;5:5101
  2. Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals.
    Authors: Hernandez Et al.
    Proc Natl Acad Sci U S A 2012;302:E1009

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