P21d hydrochloride

Key Product Details

Product Description

P21d hydrochloride is a potent and selective breast tumor kinase (Brk) inhibitor (IC₅₀ = 30 nM). Exhibits >650-fold selectively for Brk over Aurora B kinase and Lck. Downregulates SNAIL protein, restores E-cadherin expression and suppresses migration in breast cancer cells. Also active in vivo and orally bioavailable.

Product Specifications for P21d hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for P21d hydrochloride

The following data is based on the product molecular weight 483.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.07 mL	10.33 mL	20.66 mL
5 mM	0.41 mL	2.07 mL	4.13 mL
10 mM	0.21 mL	1.03 mL	2.07 mL
50 mM	0.04 mL	0.21 mL	0.41 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ito PTK6 inhibition suppresses metastases of triple-negative breast cancer via SNAIL-dependent E-cadherin regulation. Cancer Res. 2016 PMID: 27302163
• Zeng Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors. Bioorg.Med.Chem.Lett 2011 PMID: 21855335

Product Documents for P21d hydrochloride