Catalog Number: 2581
Chemical Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
Biological Activity
Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.
    Putt et al.
    Nat.Chem.Biol., 2006;2:543
  2. Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3.
    Peterson et al.
    J.Med.Chem., 2009;52:5721
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