Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50
= 0.22 μ
M). Also activates procaspase-7 in a less efficient manner (EC50
= 4.5 μ
M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50
values are 0.003 - 1.41 and 5.02 - 9.98 μ
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.
Putt et al.
Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3.
Peterson et al.