Chemical Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
Biological ActivityPAC 1 is a procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy.
Putt et al.
Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3.
Peterson et al.
Citations for PAC 1
The citations listed below are publications that use Tocris products. Selected citations for PAC 1 include:
2 Citations: Showing 1 - 2
NMDAR-Activated PP1 Dephosphorylates GluN2B to Modulate NMDAR Synaptic Content.
Authors: Chiu Et al.
Cell Rep 2019;28:332
Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size.
Authors: Yosefzon Et al.
Mol Cell 2018;70:573
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for PAC 1
There are currently no reviews for this product. Be the first to review PAC 1 and earn rewards!
Have you used PAC 1?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image