Caspase Activators: Products

Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases).

Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases.

"Caspase Activators" has 5 results in Products.
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Cisplatin

Potent pro-apoptotic anticancer agent; activates caspase-3

PETCM

Activator of caspase-3

Apoptosis Activator 2

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

PAC 1

Activator of procaspase-3; pro-apoptotic

Gambogic acid

Apoptosis inducer. Activates caspases and inhibits Bcl-2 family proteins
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