Catalog Number: 1183
Alternate Names: Pituitary Adenylate Cyclase-Activating Polypeptide 1-27
Biological Activity
Endogenous neuropeptide showing considerable homology with vasoactive intestinal peptide (VIP). Potently stimulates adenylyl cyclase.
Technical Data
  • M.Wt:
    3147.6
  • Formula:
    C142H224N40O39S
  • Sequence:
    HSDGIFTDSYSRYRKQMAVKKYLAAVL

    (Modifications: Leu-27 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    127317-03-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pituitary adenylate cyclase-activating polypeptide-27 causes a biphasic chronotropic effect and atrial fibrillation in autonomically decentralized, anaesthetized dogs.
    Hirose et al.
    J.Pharmacol.Exp.Ther., 1997;283:478
  2. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
    Michel et al.
    Pharmacol.Rev., 1998;50:143
  3. Pituitary adenylate cyclase-activating polypeptide increase [Ca2+]i in rat gonadotrophs through an inositol trisphosphate-dependent mechanism.
    Rawlings et al.
    J.Biol.Chem., 1994;269:5680

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