PACAP 6-38

Name: PACAP 6-38
Brand: Tocris Bioscience
SKU: 3236
Price: 237 USD
Availability: InStock

Tocris Bioscience | Catalog # 3236

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Citations (30)

Product Documents

Potent PAC1 receptor antagonist

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent PAC1 receptor antagonist

View all PACAP Receptor Antagonists »

Product Description

PACAP 6-38 is a potent and competitive pituitary adenylate cyclase-activating polypeptide receptor (PAC)₁ antagonist (IC₅₀ = 2 nM). Inhibits PACAP(1-27)-induced stimulation of adenylate cyclase (K_i = 1.5 nM). Antitumor activity in vivo.

Product Specifications for PACAP 6-38

Molecular Weight

4024.78

Formula

C₁₈₂H₃₀₀N₅₆O₄₅S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

143748-18-9

PubChem ID

24868185

InChI Key

BGZYREVJBMQLGS-ONKNJJKASA-N

SMILES

[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 30 publications citing the usage of this product.

Leyton PACAP(6-38) inhibits growth of prostate cancer cells. Cancer Lett. 1998 PMID: 9566707
Kojro The neuropeptide PACAP promotes a-secretase pathway for processing Alzheimer amyloid precursor protein. FASEB J. 2006 PMID: 16401644
Robberecht Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist. Eur.J.Biochem. 1992 PMID: 1321043

Product Documents for PACAP 6-38

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Product Specific Notices for PACAP 6-38

For research use only

Citations for PACAP 6-38

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