Chemical Name: (7R)-7-(Acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium-4-oxide
Biological ActivityEndogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187.
Oda et al.
Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man.
Archer et al.
Vasorelaxant effect of C16-PAF and C18-PAF on renal blood flow and systemic blood pressure in the anesthetized rat.
Handa et al.
Life Sci., 1991;49:747
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Platelet activating factor (PAF) at 100nM induced a biphasic calcium response in microglia culture. Initial release from internal source and subsequent a sustained influx.