Pam2CSK4
1 Image
Description: TLR2/6 agonist; induces TNF-α production
Biological Activity
Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.Technical Data
Formula:
C65H126N10O12S
Sequence:
CSKKKK
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)
Solubility:
Soluble to 1 mg/ml in 0.25% acetic acid
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
868247-72-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
-
Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells.
Boeglin et al.
PLoS One, 2011;6:e25542 -
Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination.
Omueti et al.
J.Biol.Chem., 2005;280:36616 -
Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation.
Schromm et al.
J.Biol.Chem., 2007;282:11030
Product Datasheets
or select another batch:
Reconstitution Calculator
Reconstitution Calculator
FAQs
No product specific FAQs exist for this product, however you may
View all Peptide FAQsTocris Peptides
VersaClone cDNA Plasmids
Reviews for Pam2CSK4
There are currently no reviews for this product. Be the first to review Pam2CSK4 and earn rewards!
Have you used Pam2CSK4?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris Bioscience is the leading supplier of novel and exclusive tools for
life science research with over 30 years' experience in the industry.
Tocris is a Bio-Techne brand.
