Biological ActivityToll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)
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Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells.
Boeglin et al.
PLoS One, 2011;6:e25542
Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination.
Omueti et al.
Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation.
Schromm et al.
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Raw macrophages were stimulated either with LPS (200 ng/ml) or Pam2CSK4 (50 nM) for 8 h to follow TNFa concentration in cell culture medium using ELISA. Pam2CSK4 induced TNFa production and release in a similar extent as LPS.