Pam2CSK4
Biological Activity
Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.Technical Data
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells.
Boeglin et al.
PLoS One, 2011;6:e25542 -
Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination.
Omueti et al.
J.Biol.Chem., 2005;280:36616 -
Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation.
Schromm et al.
J.Biol.Chem., 2007;282:11030
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Raw macrophages were stimulated either with LPS (200 ng/ml) or Pam2CSK4 (50 nM) for 8 h to follow TNFa concentration in cell culture medium using ELISA. Pam2CSK4 induced TNFa production and release in a similar extent as LPS.
