Biological ActivityToll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into T h 17 cells.
(Modifications: Cys = S-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl]-Cys
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.
Offermanns et al.
MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action.
Caproni et al.
Toll-like receptor ligands induce the expression of IF.-gamma and interleukin-17 in chicken CD4+ T cells.
St Paul et al.
BMC Res.Notes, 2012;1:616
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I use this product to activate TLR2