Pam3CSK4
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Description: TLR1/2 agonist; induces cytokine production
Purity: ≥95%
Biological Activity
Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.Technical Data
M.Wt:
1510.24
Formula:
C81H156N10O13S
Sequence:
CSKKKK
(Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys
Solubility:
Soluble to 1 mg/ml in 50% Ethanol / water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
112208-00-1
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.
Offermanns et al.
Biochem.J., 1992;282:551 -
MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action.
Caproni et al.
J.Immunol., 2012;188:3088 -
Toll-like receptor ligands induce the expression of IF.-gamma and interleukin-17 in chicken CD4+ T cells.
St Paul et al.
BMC Res.Notes, 2012;1:616
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FAQs
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Good product!
By KANG LE
on 04/24/2018
I use this product to activate TLR2
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