Catalog # Availability Size / Price Qty
1 Image
Description: TLR1/2 agonist; induces cytokine production

Purity: ≥95%

Product Details
Citations (3)
Supplemental Products
Reviews (1)

Biological Activity

Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.

Technical Data


(Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R/S)-propyl]-N-palmitoyl]-Cys

Soluble to 1 mg/ml in 50% Ethanol / water
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Suppression of ?v?6 Integrin Expression by Polymicrobial Oral Biofilms in Gingival Epithelial Cells
    J Bi, L Koivisto, A Pang, M Li, G Jiang, S Aurora, Z Wang, GR Owen, J Dai, Y Shen, D Grenier, M Haapasalo, L Häkkinen, H Larjava
    Sci Rep, 2017;7(1):4411.
  2. Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids
    KC Murphy, J Whitehead, PC Falahee, D Zhou, SI Simon, JK Leach
    Stem Cells, 2017;0(0):.
  3. High-density lipoprotein suppresses tumor necrosis factor alpha production by mycobacteria-infected human macrophages
    M Inoue, M Niki, Y Ozeki, S Nagi, EA Chadeka, T Yamaguchi, M Osada-Oka, K Ono, T Oda, F Mwende, Y Kaneko, M Matsumoto, S Kaneko, Y Ichinose, SM Njenga, S Hamano, S Matsumoto
    Sci Rep, 2018;8(1):6736.
  4. Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells.
    Offermanns et al.
    Biochem.J., 1992;282:551
  5. MF59 and Pam3CSK4 boost adaptive responses to influenza subunit vaccine through an IFN type I-independent mechanism of action.
    Caproni et al.
    J.Immunol., 2012;188:3088
  6. Toll-like receptor ligands induce the expression of IF.-gamma and interleukin-17 in chicken CD4+ T cells.
    St Paul et al.
    BMC Res.Notes, 2012;1:616

Product Datasheets

Or select another batch:
View Batch
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Pam3CSK4

The citations listed below are publications that use Tocris products. Selected citations for Pam3CSK4 include:

3 Citations: Showing 1 - 3


No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for Pam3CSK4

Average Rating: 5 (Based on 1 Review)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used Pam3CSK4?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Good product!
By KANG LE on 04/24/2018

I use this product to activate TLR2

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.