Pam3CSK4

Tocris Bioscience | Catalog # 4633

TLR1/2 agonist; induces cytokine production
Tocris Bioscience

Key Product Details

Description

TLR1/2 agonist; induces cytokine production
View all Toll-like Receptor Agonists »

Product Description

Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist; induces production of TNF-α and IL-6 in macrophages. Stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells. Promotes differentiation of naive CD4+ T cells into Th17 cells.

Product Specifications for Pam3CSK4

Molecular Weight

1510.24

Formula

C81H156N10O13S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

112208-00-1

PubChem ID

130704

InChI Key

OEDPHAKKZGDBEV-GFPBKZJXSA-N

SMILES

[H]N([C@@H](CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(O)=O)C(=O)CCCCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solubility Soluble to 1mg/ml in 50% Ethanol / water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 50 publications citing the usage of this product.

Product Documents for Pam3CSK4

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pam3CSK4

For research use only

Customer Reviews for Pam3CSK4 (3)

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  • Pam3CSK4 inducer works great
    Name: Xiaogang Wang
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: differentiated human macrophages
    Verified Customer | Posted 06/21/2021
    We used 50 ng/ml of Pam3CSK4 to treat differentiated human macrophages for 2 h at 37C and measured the IL-6 production in culture supernatants of macrophages. As shown in the attached image, Pam3CSK4 treatment, but not untreated cells, significantly induced IL-6 production in human macrophages.
    Pam3CSK4 4633
  • TLR 1/2 agonist
    Name: Tahmineh Safaie
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Raw-Blue
    Verified Customer | Posted 01/22/2020
    Raw-Blue Cell lines were treated with 125 ng/ml of PAM3CSK4 and the level of SEAP was measured. SEAP level correlates with NFkB activation
    Pam3CSK4 4633
  • Good product!
    Name: KANG LE
    Assay Type: In Vitro
    Cell Line/Tissue: THP1
    Verified Customer | Posted 04/24/2018
    I use this product to activate TLR2

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