PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.
PAR Monoclonal Antibody Affinity Purified
R&D Systems | Catalog # 4335-AMC-050
Discontinued Product
4335-AMC-050 has been discontinued.
An alternative/replacement product is available:
4335-MC-100. View all PAR/pADPr products.
Key Product Details
Species Reactivity
Validated:
Multi-Species
Cited:
Human, Mouse
Applications
Immunohistochemistry-Paraffin, Western Blot, Immunoprecipitation
Label
Unconjugated
Antibody Source
Monoclonal Clone # 10HA
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Product Specifications
Clonality
Monoclonal
Formulation, Preparation, and Storage
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: PAR/pADPr
Long Name
Poly [ADP-ribose] Polymer
Alternate Names
PAR
Additional PAR/pADPr Products
Product Documents for PAR Monoclonal Antibody Affinity Purified
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for PAR Monoclonal Antibody Affinity Purified
For research use only
Related Research Areas
Citations for PAR Monoclonal Antibody Affinity Purified
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