Parkin Antibody - BSA Free

Novus Biologicals | Catalog # NBP2-68629

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Parkin Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: LHHFRILGEEQYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGGNGLGCGFAFCRECKEAYHEGECS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Parkin Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: Parkin Antibody [NBP2-68629]

Immunocytochemistry/ Immunofluorescence: Parkin Antibody [NBP2-68629]

Immunocytochemistry/Immunofluorescence: Parkin Antibody [NBP2-68629] - Staining of human cell line SH-SY5Y shows localization to nuclear speckles.
Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629]

Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629]

Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629] - Staining of human dodenum shows moderate cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629]

Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629]

Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629] - Immunohistochemical staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts.
Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629]

Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629]

Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629] - Staining of human cerebral cortex shows moderate cytoplasmic positivity in neuropil and neurons.
Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629]

Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629]

Immunohistochemistry-Paraffin: Parkin Antibody [NBP2-68629] - Staining of human kidney shows moderate cytoplasmic positivity in cells in tubules and cells in glomeruli.

Applications for Parkin Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
Recommended conditions for ICC/IF: Fixation/Permeabilization: PFA/Triton X-100, Recommended conditions for IHC: Retrieval method: HIER pH6

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Parkin

Parkinson's disease is a common neurodegenerative disease with complex clinical features. Mutations in the gene, Parkin (PARK2), appear to be responsible for the pathogenesis of autosomal recessive juvenile Parkinsonism. Parkin plays a role in the ubiquitin-mediated proteolytic pathway by removal and/or detoxification of abnormally folded or damaged protein. Loss of this ubiquitin ligase activity appears to be the mechanism underlying pathogenesis of Parkin. Parkin may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, gpr37 accumulation, and kainate-induced excitotoxicity. It may play a role in controlling neurotransmitter trafficking at the presynaptic terminal and in calcium-dependent exocytosis. Parkin also regulates cyclin e during neuronal apoptosis and may represent a tumor suppressor gene.

Long Name

Parkinson Disease [autosomal recessive, juvenile] 2, Parkin [PARK2], transcript variant 1

Alternate Names

AR-JP, PARK2, PDJ, PRKN

Gene Symbol

PRKN

Additional Parkin Products

Product Documents for Parkin Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Parkin Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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