Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1
) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50
~ 20 μ
M), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apoptotic activity in vitro
. Inhibits angiogenesis and exhibits cardioprotective activity in vivo
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Other Product-Specific Information:
Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of activation.
Zania et al.
Parstatin: a cryptic peptide involved in cardioprotection after ischaemic and reperfusion injury.
Strande et al.