Biological ActivityParstatin (mouse) is a cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activation of caspase-3 and exhibits pro-apoptotic activity in vitro. Inhibits angiogenesis and exhibits cardioprotective activity in vivo.
Parstatin (human) also available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of activation.
Zania et al.
Parstatin: a cryptic peptide involved in cardioprotection after ischaemic and reperfusion injury.
Strande et al.
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