Catalog Number: 0571
Chemical Name: 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid methyl 2-(phenylthio)ethyl ester
Biological Activity
A specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC50 value of 1.05 μM and has no significant activity on Ca2+ channels. Active in vivo, antagonizing PAF-induced systemic hypotension and protein-plasma extravasation in rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies.
    Fernandez-Gallardo et al.
    J.Pharmacol.Exp.Ther., 1990;255:34
  2. 4-Alkyl-1,4-dihydropyridine derivatives as specific PAF-acether antagonists.
    Sunkel et al.
    J.Med.Chem., 1990;33:3205
  3. 1,4-Dihydropyridines, a new class of platelet activating factor receptor antagonists: in vitro pharmacological studies.
    Sunkel et al.
    J.Pharmacol.Exp.Ther., 1990;255:28

The citations listed below are publications that use Tocris products. Selected citations for PCA 4248 include:

4 Citations: Showing 1 - 4
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  1. Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.
    Authors: Hergott Et al.
    Mediators Inflamm 2015;125:3878
  2. Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor.
    Authors: Bachi Et al.
    J Pharmacol Exp Ther 2012;2012:610371
  3. Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice.
    Authors: Garcia Et al.
    PLoS Pathog 2010;6:e1001171
  4. Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
    Authors: Mathison Et al.
    Br J Pharmacol 2004;142:1247

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