Chemical Name: 1,4-Dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylic acid methyl 2-(phenylthio)ethyl ester
Biological ActivityPCA 4248 is a specific PAF antagonist, more potent than the ginkolide BN-52021. Inhibits rabbit platelet aggregation with an IC50 value of 1.05 μM and has no significant activity on Ca2+ channels. Active in vivo, antagonizing PAF-induced systemic hypotension and protein-plasma extravasation in rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Pharmacological actions of PCA 4248, a new platelet-activating factor receptor antagonist: in vivo studies.
Fernandez-Gallardo et al.
4-Alkyl-1,4-dihydropyridine derivatives as specific PAF-acether antagonists.
Sunkel et al.
1,4-Dihydropyridines, a new class of platelet activating factor receptor antagonists: in vitro pharmacological studies.
Sunkel et al.
Citations for PCA 4248
The citations listed below are publications that use Tocris products. Selected citations for PCA 4248 include:
4 Citations: Showing 1 - 4
Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection.
Authors: Hergott Et al.
Mediators Inflamm 2015;125:3878
Apoptotic cells contribute to melanoma progression and this effect is partially mediated by the platelet-activating factor receptor.
Authors: Bachi Et al.
J Pharmacol Exp Ther 2012;2012:610371
Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice.
Authors: Garcia Et al.
PLoS Pathog 2010;6:e1001171
Effects of cannabinoid receptor-2 activation on accelerated gastrointestinal transit in lipopolysaccharide-treated rats.
Authors: Mathison Et al.
Br J Pharmacol 2004;142:1247
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