Chemical Name: N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide
Biological ActivityPCI 34051 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.
Pipalia et al.
A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas.
Balasubramanian et al.
Citation for PCI 34051
The citations listed below are publications that use Tocris products. Selected citations for PCI 34051 include:
1 Citation: Showing 1 - 1
Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition
Br J?Cancer 2018;118(10):1359
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TGF beta high responder treated with 5 μM PCI34051 (HDAC 8 inhibitor) for 48 h. Cell lysates were analysed by western blot.