PCI 34051

Catalog # Availability Size / Price Qty
4643/10
4643/50
PCI 34051 | CAS No. 950762-95-5 | Class I Histone Deacetylases Inhibitors
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Description: Potent and selective HDAC8 inhibitor

Chemical Name: N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide

Purity: ≥98%

Product Details
Citations (1)
Reviews (1)

Biological Activity

PCI 34051 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias.

Technical Data

M.Wt:
296.32
Formula:
C17H16N2O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
950762-95-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for PCI 34051

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responder treated with 5 μM PCI34051 (HDAC 8 inhibitor) for 48 h. Cell lysates were analysed by western blot.
By Anonymous on 11/15/2019
Application: Species: Human

TGF beta high responder treated with 5 μM PCI34051 (HDAC 8 inhibitor) for 48 h. Cell lysates were analysed by western blot.

PMID: 29695769

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