PCI 34051

Tocris Bioscience | Catalog # 4643

Potent and selective HDAC8 inhibitor
Tocris Bioscience

Key Product Details

Description

Potent and selective HDAC8 inhibitor
View all Class I Histone Deacetylases Inhibitors »

Product Description

PCI 34051 is a potent and selective histone deacetylase 8 (HDAC8) inhibitor (IC50 = 10 nM). Displays >200 fold selectivity over HDAC isoforms 1, 2, 3, 6 and 10. Induces apoptosis in cell lines derived from T cell lymphomas or leukemias.

Product Specifications for PCI 34051

Molecular Weight

296.32

Formula

C17H16N2O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide

CAS Number

950762-95-5

PubChem ID

24753719

InChI Key

AJRGHIGYPXNABY-UHFFFAOYSA-N

SMILES

O=C(NO)C1=CC=C2C(N(CC3=CC=C(OC)C=C3)C=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.63 100
1eq. NaOH 5.93 20

Preparing Stock Solutions for PCI 34051

The following data is based on the product molecular weight 296.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.37 mL 16.87 mL 33.75 mL
5 mM 0.67 mL 3.37 mL 6.75 mL
10 mM 0.34 mL 1.69 mL 3.37 mL
50 mM 0.07 mL 0.34 mL 0.67 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for PCI 34051

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PCI 34051

For research use only

Customer Reviews for PCI 34051 (1)

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  • responder treated with 5 μM PCI34051 (HDAC 8 inhibitor) for 48 h. Cell lysates were analysed by western blot.
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: C3-TAg tumour cell
    Verified Customer | Posted 11/15/2019
    TGF beta high responder treated with 5 μM PCI34051 (HDAC 8 inhibitor) for 48 h. Cell lysates were analysed by western blot.
    PCI 34051 4643

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