Catalog Number: 1671
Chemical Name: 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester
Biological Activity
Selective M4 muscarinic receptor antagonist. IC50 values are 91, 6559, 3441, 950 and 7412 nM for human M4, M1, M2, M3, and M5 receptors respectively.
Technical Data
  • M.Wt:
    392.45
  • Formula:
    C23H24N2O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    23062-91-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterization of m4 selective muscarinic antagonists.
    Augelli-Szafran et al.
    Bioorg.Med.Chem.Lett., 1998;8:1991
  2. Synthesis and pharmacology of benzoxazines as highly selective antagonists at M4 muscarinic receptors.
    Bohme et al.
    J.Med.Chem., 2002;45:3094
  3. A novel muscarinic M4 receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M2 receptor sub-type.
    Kitaichi et al.
    Eur.J.Pharmacol., 1999;383:53

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