PD 118057
Discontinued Product
Chemical Name: 2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid
Purity: ≥99%
Biological Activity
PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator. Displays no major effect on INa, ICa/L, IK1 and IKs currents. Causes resting membrane hyperpolarization and decreases action potential duration in rat myocytes in vitro.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity.
Zhou et al.
Mol.Pharmacol., 2005;68:876 -
Pharmacological and biophysical isolation of K+ currents encoded by ether-a-go-go-related genes in murine hepatic portal vein smooth muscle cells.
Yeung and Greenwood
Am.J.Physiol.Cell.Physiol., 2007;292:C468 -
hERG: The long and short of it.
Duff
Heart Rhythm, 2008;5:591
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