PD 118057

Tocris Bioscience | Catalog # 2830

Selective KV11.1 (hERG) channel activator
Tocris Bioscience
Discontinued Product
2830 has been discontinued. View all Voltage-gated Potassium Channel Activators products.

Key Product Details

Description

Selective KV11.1 (hERG) channel activator
View all Voltage-gated Potassium Channel Activators »

Product Description

PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator. Displays no major effect on INa, ICa/L, IK1 and IKs currents. Causes resting membrane hyperpolarization and decreases action potential duration in rat myocytes in vitro.

Product Specifications for PD 118057

Molecular Weight

386.27

Formula

C21H17Cl2NO2

Storage

Store at -20°C

Purity

≥99% (HPLC)

Chemical Name

2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid

CAS Number

2830[313674-97-4

PubChem ID

9864959

InChI Key

ZCQOSCDABPVAFB-UHFFFAOYSA-N

SMILES

ClC(C(Cl)=C3)=CC=C3CCC(C=C2)=CC=C2NC1=C(C(O)=O)C=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.63 100
Ethanol 7.73 20

Preparing Stock Solutions for PD 118057

The following data is based on the product molecular weight 386.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.94 mL 25.89 mL
5 mM 0.52 mL 2.59 mL 5.18 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for PD 118057

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 118057

For research use only

Customer Reviews for PD 118057 (1)

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  • Amazing Kv channel activator
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 10/23/2018
    Amazing Kv channel activator, shows high channel activation on almost all cell lines that express Kv channels. Performs great on experimental conditions, is stable and would buy again soon.
    PD 118057 2830

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