Potent and selective, nonpeptide CCK2
receptor antagonist (IC50
values are 2.8 and 1232 nM for CCK2
respectively) that displays negligible affinity at GABAA
, benzodiazepine, substance P, neurotensin, opioid, bradykinin and 5-HT3
> 10 μ
M). Exhibits anxiolytic activity in elevated plus maze and social interaction tests and increases food intake in rats.
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All Tocris products are intended for laboratory research use only.
CholecystokininB receptor antagonist increases food intake in rats.
Dorre and Smith
Suppression of conditioned fear by administration of CCKB receptor antagonist PD135158.
Tsutsumi et al.
Development of a class of selective cholecystokinin type B receptor antagonists having potent anxiolytic activity.
Hughes et al.