PD 144418 oxalate
Chemical Name: 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate
Biological ActivityPD 144418 oxalate is a high affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418.
Lever et al.
The pharmacology of the novel and selective sigma ligand, PD 144418.
Akunne et al.
Citations for PD 144418 oxalate
The citations listed below are publications that use Tocris products. Selected citations for PD 144418 oxalate include:
2 Citations: Showing 1 - 2
Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
Authors: Sánchez-Blázquez Et al.
Int J Neuropsychopharmacol 2018;21:938
Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
Authors: Navarro Et al.
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