High affinity, selective σ1
values are 0.08 and 1377 nM for σ1
respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.
Soluble to 50 mM in DMSO
Desiccate at RT
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Sold for research purposes under agreement from Pfizer Inc.
The pharmacology of the novel and selective sigma ligand, PD 144418.
Akunne et al.
Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418.
Lever et al.
The citations listed below are publications that use Tocris products. Selected citations for PD 144418 oxalate include:
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