PD 144418 oxalate
Tocris Bioscience | Catalog # 2606
Key Product Details
Description
Product Description
PD 144418 oxalate is a high affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Product Specifications for PD 144418 oxalate
Molecular Weight
Formula
Storage
Purity
Chemical Name
CAS Number
PubChem ID
InChI Key
SMILES
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.62 | 50 |
Preparing Stock Solutions for PD 144418 oxalate
The following data is based on the product molecular weight 372.42.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.37 mL | 26.85 mL | 53.70 mL |
| 2.5 mM | 1.07 mL | 5.37 mL | 10.74 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 25 mM | 0.11 mL | 0.54 mL | 1.07 mL |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.
- Lever Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J.Pharmacol.Exp.Ther. 2014 PMID: 25100754
- Akunne The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 1997 PMID: 9144641
Product Documents for PD 144418 oxalate
Certificate of Analysis
To download a Certificate of Analysis, please enter a lot or batch number in the search box below.
Product Specific Notices for PD 144418 oxalate
For research use only
Citations for PD 144418 oxalate
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