PD 144418 oxalate

Tocris Bioscience | Catalog # 2606

High affinity, selective σ1 ligand
Tocris Bioscience
Discontinued Product
2606 has been discontinued. View all Sigma1 Receptor Ligands products.

Key Product Details

Description

High affinity, selective σ1 ligand

Product Description

PD 144418 oxalate is a high affinity, selective σ1 ligand (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively). Displays no significant activity at a wide range of other receptors, ion channels and enzymes. Antagonizes mescaline-induced scratching in mice following i.p. administration. Also attenuates cocaine-induced hyperactivity in mice.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PD 144418 oxalate

Molecular Weight

372.42

Formula

C18H22N2O.C2H2O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate

CAS Number

1794760-28-3

PubChem ID

9817231

InChI Key

FOQRKFCLRMMKAT-UHFFFAOYSA-N

SMILES

O=C(O)C(O)=O.CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.62 50

Preparing Stock Solutions for PD 144418 oxalate

The following data is based on the product molecular weight 372.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.37 mL 26.85 mL 53.70 mL
2.5 mM 1.07 mL 5.37 mL 10.74 mL
5 mM 0.54 mL 2.69 mL 5.37 mL
25 mM 0.11 mL 0.54 mL 1.07 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

Product Documents for PD 144418 oxalate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PD 144418 oxalate

For research use only

Citations for PD 144418 oxalate

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