PD 173212

Catalog # Availability Size / Price Qty
3552/10
PD 173212 | CAS No. 217171-01-2 | Cav2.x Channel Blockers
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Description: Potent CaV2.2 blocker

Chemical Name: N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide

Product Details
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Biological Activity

Potent N-type voltage-gated calcium channel blocker (IC50 = 36 nM). Displays selectivity over K+, Na+ and L-type Ca2+ channels. Prevents tonic seizures in the audiogenic seizure model in vivo.

Technical Data

Formula:
C38H53N3O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
217171-01-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structure-activity relationships of N-methyl-N-aralkyl-peptidylamines as novel N-type calcium channel blockers.
    Hu et al.
    Bioorg.Med.Chem.Letts., 1999;9:2151

Product Datasheets

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