Chemical Name: (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide
Biological ActivityPD 176252 is a non-peptide gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 0.17 and 1.0 nM for BB1 and BB2 respectively). Inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Gastrin-releasing peptide/neuromedin B receptor antagonists pD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors.
Schepetkin et al.
PD 176252 - the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist
Ashwood et al.
Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells
Moody et al.
Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells
Moody et al.
Citations for PD 176252
The citations listed below are publications that use Tocris products. Selected citations for PD 176252 include:
2 Citations: Showing 1 - 2
Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.
Authors: Atkins Et al.
PLoS One 2010;5:e12612
Characterization of putative GRP- and NMB-receptor antagonist's interaction with human receptors.
Authors: González Et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for PD 176252
There are currently no reviews for this product. Be the first to review PD 176252 and earn rewards!
Have you used PD 176252?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image