PD 176252

Catalog # Availability Size / Price Qty
2602/10
Cat.No. 2602 - PD 176252 | C32H36N6O5 | CAS No. 204067-01-6
1 Image
Description: GRP (BB2) and NMB (BB1) receptor antagonist

Chemical Name: (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

Non-peptide gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 0.17 and 1.0 nM for BB1 and BB2 respectively). Inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM).

Technical Data

M.Wt:
584.67
Formula:
C32H36N6O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
204067-01-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for PD 176252

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